Micky van de Ven Double Halts The Toffees' Unbeaten Streak at Brand New Stadium
The Dutch defender became the initial defender to score two goals in a English top-flight game for Tottenham since Jan Vertonghen in March 2013.
At a glance
The Spurs defender heads home twice in opening period
Everton's defender has goal ruled after VAR review
Pape Matar Sarr nets third in dying moments
This loss is Everton's initial at Hill Dickinson Stadium
Micky van de Ven scored twice as Tottenham extended their winning streak in away games in the top division and delivered Everton their initial loss at their new home.
Everton were unbeaten in their last five matches at their new ground at Bramley-Moore Dock, having departed Goodison Park behind after 133 years at the end of the previous campaign.
But Spurs captain Van de Ven pounced on two occasions from set-pieces in the opening 45 minutes to put their strong form at risk, and they were unable to mount a comeback before the midfielder - assisted by ex-Everton forward the Brazilian - nodded in a third to seal the victory.
Jake O'Brien believed he had equalized the scores a short while after the defender's first goal, glancing a powerful header past Guglielmo Vicario from an set-piece.
The Portuguese striker, in the meantime, missed a number of opportunities, while Vicario made a series of excellent saves to guarantee the London club went five matches on the road unbeaten in the English top flight.
But the video assistant referee intervened, advising the match official to check the goal on the pitchside monitor and the referee ruled that the winger and the attacker were in offside positions and had interfered with the Spurs keeper.
This victory moves Thomas Frank's side into third place in the Premier League, a handful of points off local foes and table-toppers Arsenal.
Everton stay 14th and are six points clear of the relegation zone.
Tottenham analysis: The defender fulfils role at each end of pitch
After a uninspiring weekday performance in the European competition against the French side, where they mustered a mere attempts on target, Frank chose Randal Kolo Muani up front instead of ex-Everton forward the Brazilian.
The new arrival was failed to make much of an impact before being replaced for the substitute after 60 minutes on the field, but it emerged he proved unnecessary in the final outcome.
Defender Van de Ven transformed into an offensive threat to be reckoned with.
Spurs' first goal came from a cleverly executed corner routine, with the midfielder directing the ball toward the face of goal for an free Van de Ven to head home.
And the captain - filling in as skipper in Cristian Romero's absence - added his second in first-half stoppage time as he outjumped the England keeper to head home.
The Dutchman was equally outstanding in defensive duties, partnering effectively with his defensive colleague as the pair handled excellently with the numerous deliveries thrown their way by Everton.
Toffees breakdown: Everton missing finishing touch
Everton's new home had been a happy hunting ground, but it seems the novelty may have worn off somewhat and supporters headed to the exits after Sarr's final goal for Tottenham.
The break in the team's unbeaten home run won't be a major worry for David Moyes, but their striker situation will be.
Beto and Thierno Barry - the Toffees' two recognised centre-forwards - had scored only a single goal between them before the weekend's match.
And they were failed to add to that poor record on a wet and gloomy night on in Liverpool.
Beto's form was summed up when he chose to overhead kick a golden opportunity from close range, even with having room and opportunity to reposition for a more conventional shot that would have challenged the keeper.
Barry, too, was unable to make an impact after coming on for the starter in the 65th minute.
It wasn't for a shortage of opportunity. Most of Everton's attacks came through the winger and Ndiaye, who relentlessly delivered threatening balls into the Tottenham penalty area.
Upcoming fixtures for these two sides?
The Toffees: The team head to the Stadium of Light in the Premier League on early November at 20:00 GMT.
Tottenham: Spurs travel to Newcastle's ground on Wednesday, 29 October for their fourth-round League Cup match against Newcastle.